MUST KNOW ABOUT STATINS !

STATINS

3 HMGCoA ( 3 hydroxy 3 methylglutaryl coenzyme A) reductase inhibitor,has multiple “pleiotropic” actions.

Potent anti-inflammatory

Vasculoprotective

Antitoxidative

Increases nitric oxide release

Attenuate myocardial “reperfusion” injury

Anti-thrombotic

Lipid-stabilizing

Beneficial effects on endothelial function

Decreases circulating levels of adhesion molecules (ICAM) which are implicated in endothelial dysfunction after CPB

Help in ventricular remodelling after AMI

Decreases mortality after surgery

Decreases need for postoperative renal replacement therapy-may be due to anti inflammatory effects

Decreases atrial fibrillation in cardiac surgery

According to ACC/AHA guidelines continue statins preoperatively

Postoperative withdrawal of statins is associated with increased mortality after CABG.

www.cardiacanaesthesia.in

- by Dr Amarja