3 HMGCoA ( 3 hydroxy 3 methylglutaryl coenzyme A) reductase inhibitor,has multiple “pleiotropic” actions.
Increases nitric oxide release
Attenuate myocardial “reperfusion” injury
Beneficial effects on endothelial function
Decreases circulating levels of adhesion molecules (ICAM) which are implicated in endothelial dysfunction after CPB
Help in ventricular remodelling after AMI
Decreases mortality after surgery
Decreases need for postoperative renal replacement therapy-may be due to anti inflammatory effects
Decreases atrial fibrillation in cardiac surgery
According to ACC/AHA guidelines continue statins preoperatively
Postoperative withdrawal of statins is associated with increased mortality after CABG.